All Bosses in Resident Evil 4 Remake, Ranked

A survival horror without bosses is like a sea without fish, like the Dead Sea. You don’t want that, and Resident Evil knows it too, so they do their best to include vicious bosses. You’re likely to lose your sleepover. The bosses in Resident Evil 4 are an impressive bunch. You’ll find some of them in the remake, along with a few surprises Capcom has in store for you. Others got the boot, having been written off the game completely. Campcom specifically got rid of the U-3 boss fight completely, perhaps because U-3 never had any significant bearing on the plot.  

Still, with the new changes and updates, newcomers and longtime fans are sure to have a great time mowing down the bosses in the Resident Evil 4 remake. If you’re curious to know which bosses are the best, whether based on how unique, tough, or downright impressive they are, stick around till the end of our list of all bosses in the Resident Evil 4 remake ranked. Make sure to look out for our tips on how to defeat them too.

12. Ramon Salazar

Ramon Salazar is best described as a mouthful of tentacles. Despite his massive size, he’s pretty agile and attacks by spitting a gross, fatal acid at you. It’s funny because Ramon Salazaar would taunt you for most of the game as a short, wrinkled aristocrat. Then, later, he’s transformed into an insect-like beast.

As he crawls across the ceiling, it’s apparent Ramon Salazar is a threat you can’t ignore much longer. The remake elevates this, giving Salazar’s transformation its own spectacle instead of the original’s merging with Queen Plaga.

How to Defeat Ramon Salazar

Firepower is your best friend. Just try aiming at him when he stops and opens his mouth to spit at you. The fight isn’t as challenging as other boss fights. However, the acid is quite lethal, so try to avoid them landing on you. Once Ramon Salazar falls to the ground, use the melee button to kill him.

11. Jack Krauser

Before, it was a quick-time event cutscene with Krauser. It seems, however, that Krauser made an impression, given that he now has a full boss fight dedicated to himself. With just a knife in hand, players will have to master all their melee brawl skills to take him down.

It’s quite an interesting fight, given Leon and Krauser’s shared military past and his former mentor.

How to Defeat Jack Krauser

The stakes are higher, given that you don’t have your high-grade weapons to rely on. Still, it’s a pretty grand knife fight that requires accurate timing and parries. If you deduce Krauser’s pattern, you’ll have an easier time delivering consecutive melee attacks that should end the fight in a relatively shorter time.  

10. Garrador

Garrador is a blind giant monster, which means that his hearing senses are enhanced. In the remake, Garrador is a sight to behold, spotting a menacing undertone and claustrophobic feel to his windowless dungeon. He has long metal claws on his arms that easily kill you with one fell swing. As soon as Garrador hears you, he charges at you, swinging his claws blindly and mowing down anything in its path.

How to Defeat Garrador

The fight with Garrador needs stealth a lot more than aggression. You can also get smart and try to mislead him with noises. Just make sure to safely haul yourself out of his wild slashes. Once you have the chance, fire shots at his back, where his weak point is at. And when the Plaga sprouts from the back, fire as many shots as you can until you kill it.

9. Del Lago

Fresh into the Resident Evil 4 remake, players will come face to face with Del Lago, the first boss fight of the game. Not to worry, though, as Del Lago is actually pretty reasonably balanced and, honestly, a breeze to defeat.

Del Lago looks like a giant lake monster. It lives underwater and constantly resurfaces to crash into you and kill you. While you can fight it from above ground, you may want to get in the boat and aim your harpoon toward its mouth.

How to Defeat Del Lago

Simply pay attention to Del Lago’s signature moves, which you have to do for all boss fights anyway. Once you do, hit it over and over again with a harpoon, preferably from the time it starts dragging your boat and again when it resurfaces from the water and starts coming at you until you kill it.

8. Verdugo

Verdugo has two things working for him: a long, bladed tail and sharp claws for his hands. Either one is deadly, constantly slashing his way around. He easily climbs on walls and slips through the vents, constantly springing on you when you least expect it. With the remake, he looks even more terrifying, with the tendrils sprouting out of his mouth and his look refined to perfection.

How to Defeat Verdugo

Fortunately, Verdugo has a weakness. He falls at the mercy of liquid nitrogen. So, to defeat him, simply freeze him with liquid nitrogen, then fire shots at him. Careful not to miss. Or, rocket-launch him into oblivion for a much shorter fight.

7. Twin Garradors 

The Twin Garradors’ power is amplified by other enemies that appear as well. This makes it a little difficult to remain quiet as you try to take them down, one at a time. Just remember that although the Garaddors can’t see, they’re quite good listeners who can hear even the slightest bit of disturbance. 

How to Defeat the Twin Garradors

Defeating the Twin Garradors requires the same principles as defeating the one. However, it’s a little more complicated when there are two of them. You may want to deal with the cultists first while taking care not to alert the Garradors to your presence. Then, aim for the Garradors' weak points on their backs, making sure to dodge incoming attacks and keep track of where each one is.

6. El Gigante

El Gigante is quite a huge beast, towering over everyone else. Buildings, too. He has quite the story about how Los Illuminados transformed him into a massive bioweapon. Perhaps the most vicious part of fighting El Gigante is that there is more than one of these creatures. 

On the one hand, all of their moves are similar to some extent, so defeating them, at least on the second try, will come easier. On the other hand, they modify themselves, sometimes wearing armor or appearing more than one El Gigante at the same spot. Just don’t let him pick you up and crash you, because chances are the back pain will cost you dearly.

How to Defeat El Gigante

It’s largely a similar recipe to follow for all El Gigantes. Simply shoot it as many times as possible. When La Plaga starts sprouting from its back, it signals El Gigante’s weak point is now exposed. Continue shooting it until it starts to stagger, then climb onto the monster’s back and knife straight into its la Playa sprouts. 

El Gigante isn’t a piece of cake to defeat, especially since it heals itself quickly. When it does, though, repeat the same process over and over until you finally kill it.

5. El Gigante Armored

El Gigante Armored is the same creature as El Gigante, except he has armor. That means it’ll take a much high-powered weapon to take him out. He comes after fighting El Gigante, so you should have a nice recall of how to defeat him.

How to Defeat El Gigante Armored

Take out El Gigante, armored, with a cannon. Alternatively, you may aim for the head, which is, thankfully, unprotected by the armor.

4. El Gigante & El Gigante Armored

Again, you’ll fight El Gigante, with the difference being that there are two of them: one armored, the other unarmored.

How to Defeat El Gigante & El Gigante Armored

You could sweat it and try to kill them one at a time. However, the easiest way out is to use the trap door to drop them into the lava. Nice and easy.

3. Bitores Mendez

Here’s a guy who’s a sight to see. Once a village chief, Bitores Mendez suffers from an insidious mutation of an extended spine. Literally, the upper and lower bodies are held together by an elongated, exposed spine. His legs sprout like an arachnid through his back, and, well, thus, begins the fight with the human spider. 

It gets worse. When the fight ensues, Mendez mutates further into an even more realistic spider creature, crawling around in fast motion and climbing up walls like a fly. The whole situation demands adapting and quickly moving on your feet. All along, the building you’re trapped in burns down around you.

How to Defeat Bitores Mendez

Because of how menacingly tall the guy is, you’ll want to climb the ladder to the upper floor. That way, Mendez’s weak point, an eye, is exposed on his back. Fire as many shots as you can right to the eye, leading to his body being into two.

The fight’s not done, though. Mendez will crawl up to where you are, fast. Dodge his attacks while firing shots at him. You’ll need ammunition and firepower to get the job done. And taking advantage of the explosive barrels Mendez throws at you by shooting them down as soon as he picks them up and doing more damage to him.

2. Mutated Krauser

With an emotional throwdown already established, players will have to fight a mutated Krauser later in the game. This time, Krauser has a deadly arm blade capable of killing you in one or two strikes.

While not the hardest boss fight, Mutated Krauser is the most emotional fight with a tangible backstory. In the end, Krauser collapses on the ground, gestures to his knife, and tells Leon to do what he has to do. Leon then contemplates Krauser’s will before plunging the knife into his chest.

How to Defeat Mutated Krauser

You’ll have your full arsenal at your disposal, so make sure to parry his attacks with your knife and high-power weapons to shoot him down. Watch out for Krauser’s right arm, which he uses as a shield. When his guard is down, continue shooting at him.

1. Osmund Saddler

In the final showdown, Osmund Saddler wraps up the Resident Evil 4 remake with a bang. He’s one of the toughest bosses to beat, using both acid and claw attacks. He’s also a sight to see, with countless arachnid-like limbs and appendages and two eyes on each leg joint.

Saddler’s a menace, thanks to his ability to recover after a short time and summon flying parasites to help him mid-fight. Once he’s regained his strength, he returns, having replenished his health. This fight can go on and on for a while. At some point, he mutates into a mass of tentacles that can shred you to pieces.

How to Defeat Osmund Saddler

Aim for the eyes. This will stun him and make him stumble. Then, aim for his central eye. You should see it marked with double-white arrows. Make sure to use a high-power weapon to finish him off. 

When the flying parasites come out, shoot as many as you can. Then, repeat the process of aiming for his eyes. Once he mutates, aim for the central orange blister. You can even use a rocket launcher, which Ada passes on to you.

There you go, all the bosses in the Resident Evil 4 remake ranked. Do you agree with our ranking? Let us know down in the comments or over on our socials here.